"Abnormal centrosome and centriole numbers are frequently detected in tumor cells where they can contribute to mitotic aberrations that cause chromosome missegregation and aneuploidy. The molecular mechanisms of centriole over-duplication in malignant cells, however, are poorly characterized," scientists in the United States report (see also Cancer Research).
"Here, we show that the core SKP1-cullin-F-box component cullin 1 (CUL1) localizes to maternal centrioles and that CUL1 is critical for suppressing centriole over-duplication through multiplication, a recently discovered mechanism whereby multiple daughter centrioles form concurrently at single maternal …
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